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Your question is moot because you're overthinking your issue. There is no 'general reader' because we all live in different bubbles and have different knowledge bases. For example: I'm currently wr...
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Source: https://writers.stackexchange.com/a/48466 License name: CC BY-SA 4.0 License URL: https://creativecommons.org/licenses/by-sa/4.0/
#2: Initial revision
Your question is moot because you're overthinking your issue. There is no 'general reader' because we all live in different bubbles and have different knowledge bases. For example: I'm currently writing a political thriller. The characters are discussing FLOTUS, the ACLU, the NASDAQ and 401Ks. I am aware that 95% of the planet has no idea what I'm talking about. The same issues arise when writing medical dramas: the characters discuss whipples, sux, ex-laps, TBIs and other issues. If the reader has no medical training - they've no idea what's going on. To answer your question: between ER and Grey's Anatomy . . . these series have over 700 episodes. In the UK the series Casualty passed 1000 episodes many years ago. Anything the reader doesn't understand is jargon (whether of not word is a real thing). They will put up with it so long as its embedded in good story telling and the writer does not stop the story to explain.