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I think it's going to depend on what the reasons are. If the antagonist (Andrew) is framing the protagonist (Peter), then Andrew wants Peter to take the blame for something which Peter didn't do. ...
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#4: Attribution notice removed
Source: https://writers.stackexchange.com/a/4293 License name: CC BY-SA 3.0 License URL: https://creativecommons.org/licenses/by-sa/3.0/
#3: Attribution notice added
Source: https://writers.stackexchange.com/a/4293 License name: CC BY-SA 3.0 License URL: https://creativecommons.org/licenses/by-sa/3.0/
#2: Initial revision
I think it's going to depend on what the reasons are. If the antagonist (Andrew) is framing the protagonist (Peter), then Andrew wants Peter to take the blame for something which Peter didn't do. But then Andrew is going to help Peter out of the mess which Andrew created. So does that mean Andrew wants Peter to owe him? Does Peter know Andrew framed him in the first place, or is the idea that Andrew looks like he's riding to Peter's rescue from dire but unrelated circumstances? Or does Andrew intend in Act I for Peter to suffer, and then somewhere in Act II Andrew changes his mind and realizes he has to save Peter instead? In that case, Andrew would feel like he owes Peter instead, because he started the entire problem. But he can't reveal that to Peter, or Peter will be furious with Andrew for getting Peter into trouble in the first place. Once you've resolved the Why, the When becomes clearer.